The family were in a Mini Cooper involved in the incident on the A82 at Torlundy just after 17:30 on Thursday. Police confirmed the dead mother was aged 26 and the father was 25. The 56-year-old female driver of a Ford Fiesta freed from the wreckage by firefighters was taken to hospital in Fort William with serious but not life-threatening injuries. The A82 around the scene of the crash was closed for 11 hours to allow for a police investigation. Police Scotland has appealed for witnesses.
Supt Simon Bradshaw said: "Inquiries are continuing into the incident and I would ask anyone with information or dashcam footage who has not yet come forward to please get in touch."
Fort William and Ardnamurchan councillor Andrew Baxter said the "thoughts and prayers of everyone in Lochaber" would be with those affected by the crash.
He said: "This is devastating news for the family and friends of those who have been tragically killed in this accident.
"What I have seen on local social media is great sadness."
Kate Forbes, SNP MSP for Skye, Lochaber and Badenoch, tweeted: "This is extremely sad news. Thinking of the families and friends who are dealing with the shock of all of this."