The area around the Bab al-Salam crossing has been bombed on previous occasions At least 43 people have been killed in a car bombing near the border between Syria and Turkey, activists say.
A car filled with explosives was reportedly blown up in the Karaj Sajou area, near the Bab al-Salam crossing in the northern province of Aleppo.
The UK-based Syrian Observatory for Human Rights reported that five women and three children were among the dead.
A video posted online appeared to show smoke rising from burning vehicles, charred corpses and scattered luggage.
"Oh God, may you punish them!" one man can be heard shouting.
The head of the Syrian Observatory, Rami Abdul Rahman, told the Associated Press that the explosion occurred at a garage used by passengers heading to or coming from the border crossing.
It was not immediately clear if it had been a suicide bombing, he added.